Science-Backed Ingredients

Crosslinked hyaluronic acid optimized for longer-lasting surface hydration and improved barrier metrics versus linear HA.

A gentle polyhydroxy acid (PHA) that exfoliates while supporting hydration and skin comfort; suitable for sensitive skin.

Pro‑vitamin B5 supports barrier recovery, reduces TEWL, and improves hydration; soothing on compromised skin.

Amino‑acid derived anionic surfactant noted for mildness; generally non‑irritating when properly formulated.

Mild glutamate‑based surfactant; non‑irritating in standard dermal tests.

Amino acid surfactant reviewed by CIR; related compounds in the same family showed no irritation or sensitization in human studies.

Chelating agent and preservative booster; generally non-irritating and non-sensitizing in intact skin, but positive sensitization reactions observed with use on damaged/compromised skin barriers.

Natural multifunctional deodorant active derived from castor oil and palm glycerin; classified as bacteriostatic with microbiome-friendly properties, preferentially inhibiting S. aureus over beneficial S. epidermidis. OECD testing confirms non-sensitizing, non-irritating, non-mutagenic, readily biodegradable profile.

Plant-derived humectant that draws moisture into skin; supports healthy barrier function and helps soothe inflammatory conditions like eczema. Generally well-tolerated by most skin types including sensitive skin, with side effects described as rare.

Plant-derived extracts from sunflower seeds/flowers; non-irritating and non-sensitizing in cosmetic product testing up to 10%. Contains 2S albumins (potential allergens). Panel concluded safe as used for 9 seed/flower-derived ingredients but recommends persons with seed/nut protein allergies avoid inhalable products.

Lipid-soluble antioxidant and skin conditioning agent; protects against UV-induced oxidative damage and lipid peroxidation. Demonstrates photoprotective effects by increasing minimal erythema dose (MED) and reducing inflammation. Inhibits contact dermatitis and supports skin barrier function recovery in damaged skin. Exhibits anti-inflammatory properties and reduces erythema in clinical and preclinical studies

Anti-inflammatory and skin conditioning agent derived from chamomile; demonstrates penetration enhancement properties and well-absorbed following dermal application. Exhibits skin lightening effects by inhibiting melanogenesis through lowering intracellular cAMP levels. Safe as used in cosmetics at concentrations up to 1%, with NOAEL of 200 mg/kg/day in dermal toxicity studies. Non-mutagenic and non-phototoxic in preclinical testing.

Lipophilic skin-identical lipid and essential component of the epidermal permeability barrier; functions as hair conditioning agent and skin conditioning agent-miscellaneous. Natural constituent of stratum corneum comprising approximately 50% of lipid weight and 5% of total weight. Remains primarily in epidermis without deeper penetration. Non-irritating to skin and eyes in clinical studies; non-sensitizing in multiple animal models. Oral NOAEL >2000 mg/kg with no systemic toxicity observed. Non-mutagenic in comprehensive genotoxicity testing.

Naturally-occurring lipid emulsifier and skin conditioning agent; essential component of cell membranes and metabolic precursor for steroid hormones, bile salts, and vitamin D3. Non-irritating to skin (PII = 0) and minimally irritating to eyes when tested neat. Minimal to mild cumulative skin irritant in clinical studies; non-sensitizing and non-photosensitizing in human maximization and photopatch tests. Dermal LD50 >2000 mg/kg bw; oral LD50 >2000 mg/kg bw. Non-mutagenic in bacterial and mammalian cell assays. Safe at concentrations up to 5% in cosmetics based on comprehensive clinical testing.

High‑clarity rheology modifier; safe as used in cosmetics.

Emulsifying agent, and skin/hair conditioning agent derived from soybean, egg, or corn; ubiquitous component of cell membranes consisting primarily of phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylinositol. Non- to minimally irritating to skin and eyes in human studies; non-sensitizing and non-photosensitizing in clinical testing. GRAS for food use; oral LD50 >5 g/kg bw. Safe at concentrations up to 50% based on extensive clinical experience.

Emollient, emulsifier, and viscosity regulator. Non-irritating to mildly irritating to skin and eyes at concentrations up to 100%. Non-sensitizing in human repeated insult patch tests. Safe for topical application at concentrations 0.1% to 50% CIR Expert Panel conclusion.

Clinical testing demonstrated niacinamide produced no stinging sensation at concentrations up to 10%, no irritation at concentrations up to 5% in use tests, and no irritancy in 21-day cumulative irritation tests. The ingredient was non-sensitizing and non-photosensitizing in human studies.

Clinical evidence supports using aloe vera to retain skin moisture and integrity while preventing ulcers. The review concluded that aloe vera can be safely applied as a main treatment or complementary therapy alongside current medical methods to improve wound healing outcomes. No significant adverse effects were reported in the reviewed clinical trials, confirming its safety profile for topical dermatological applications.

AHA and pH adjuster; at appropriate concentrations supports skin renewal while maintaining tolerance.